Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene

@article{Perroud2013ResponseTP,
  title={Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene},
  author={N. Perroud and A. Salzmann and P. Prada and R. Nicastro and M. Hoeppli and S. Furrer and S. Ardu and I. Krejci and F. Karege and A. Malafosse},
  journal={Translational Psychiatry},
  year={2013},
  volume={3}
}
Downregulation of brain-derived neurotrophic factor (BDNF) gene expression with corresponding increased methylation at specific promoters has been associated with stressful experiences in early life and may explain later adulthood psychopathology. We measured the percentage of methylation at BDNF CpG exons I and IV as well as plasma BDNF protein levels in 115 subjects with borderline personality disorder (BPD) and 52 controls. BPD subjects then underwent a 4-week course of intensive dialectical… Expand
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