Response to noradrenaline and histamine in normal and sensitized guinea pig aorta and its relation to endothelium.


Pharmacological reactivity of sensitized blood vessels has been less studied than that of airways. Aorta rings were obtained from normal and actively sensitized guinea pigs and prepared for isometric recording of tension changes. Noradrenaline (10 nM-10 microM), histamine (0.1 microM-0.1 mM) and KCl (10-100 mM) produced concentration-related contractions of… (More)


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