Response to learned threat: An FMRI study in adolescent and adult anxiety.

  title={Response to learned threat: An FMRI study in adolescent and adult anxiety.},
  author={Jennifer C. Britton and Christian Grillon and Shmuel Lissek and Maxine A. Norcross and Kristin L. Szuhany and Gang Chen and Monique Ernst and Eric E. Nelson and Ellen Leibenluft and Tomer Shechner and Daniel S. Pine},
  journal={The American journal of psychiatry},
  volume={170 10},
OBJECTIVE Poor threat-safety discrimination reflects prefrontal cortex dysfunction in adult anxiety disorders. While adolescent anxiety disorders are impairing and predict high risk for adult anxiety disorders, the neural correlates of threat-safety discrimination have not been investigated in this population. The authors compared prefrontal cortex function in anxious and healthy adolescents and adults following conditioning and extinction, processes requiring threat-safety learning. METHOD… CONTINUE READING
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