Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain.

@article{RibaBosch2004ResponseTK,
  title={Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain.},
  author={A Riba-Bosch and Je{\'u}s P{\'e}rez-Clausell},
  journal={Neuroscience},
  year={2004},
  volume={125 3},
  pages={803-18}
}
A pool of zinc is present in synaptic vesicles in a population of glutamatergic neurones. Zinc appears to modulate synaptic transmission and cause neuronal death. The status of vesicular zinc, neuronal death and glial reaction in the rat forebrain was analysed after a systemic injection of kainic acid in order to establish a model for future studies on zinc function. Rats received a systemic injection of kainic acid (10 mg/kg) and were killed 3, 6, 12, 24 and 48 h post-treatment. Timm's method… CONTINUE READING
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