Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)

@article{Egerton2018ResponseTI,
  title={Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)},
  author={Alice Egerton and Brian Villumsen Broberg and Neeltje E.M . van Haren and Kate Merritt and Gareth J. Barker and David J. Lythgoe and Roc{\'i}o Perez-Iglesias and Lone Baandrup and Signe D{\"u}ring and Kyra-Verena Sendt and James M Stone and Egill Rostrup and Iris E. C. Sommer and Birte Yding Glenth\oj and R. S. Kahn and Paola Dazzan and Philip K. McGuire},
  journal={Molecular Psychiatry},
  year={2018},
  pages={1-11}
}
Conventional antipsychotic medication is ineffective in around a third of patients with schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated whether response to antipsychotics is related to brain glutamate levels prior to treatment. Proton magnetic resonance spectroscopy was used to measure glutamate levels (Glu/Cr) in… CONTINUE READING