Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

@article{Granoff1984ResponseTI,
  title={Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.},
  author={Dan M Granoff and Janardan P Pandey and Eyla G Boies and Janet E Squires and Robert S. Munson and Brian K. Suarez},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={74 5},
  pages={1708-14}
}
In experimental animals, immune responses to certain antigens are regulated by immunoglobulin allotype-linked genes. In an effort to detect such genes in humans, we examined the antibody responses of 74 healthy children with different Km(1) or Gm(23) allotypes to a Haemophilus influenzae type b vaccine (type b polysaccharide capsule-pertussis vaccine). The anticapsular antibody responses of black or white children with the Km(1) allotype were 4.6- to 9.5-fold higher than those of children who… CONTINUE READING

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