Response to hydroxycarbamide in pediatric β-thalassemia intermedia: 8 years’ follow-up in Egypt

@article{ElBeshlawy2014ResponseTH,
  title={Response to hydroxycarbamide in pediatric β-thalassemia intermedia: 8 years’ follow-up in Egypt},
  author={Amal M El-Beshlawy and Mona Kamal El-Ghamrawy and Mona Abou El-Ela and Fadwa Said and Sonia Adolf and Abdel-Rahman Ahmed Abdel-Razek and Rania Ismail Magdy and Amina Abdel-Salam},
  journal={Annals of Hematology},
  year={2014},
  volume={93},
  pages={2045-2050}
}
Hydroxycarbamide (hydroxyurea or HU) has been shown to increase fetal hemoglobin (HbF) in patients with β-thalassemia intermedia (TI). The reported effects of HU in increasing the total hemoglobin (Hb) have been inconsistent. Studies of long-term therapy with HU in pediatric TI are rather uncommon. A retrospective observational study was carried out to evaluate the clinical responses to HU in Egyptian patients with β-TI. One hundred patients; children (n = 82, mean age 9.9 ± 4.1 years) and… CONTINUE READING

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