Response to first drug trial predicts outcome in childhood temporal lobe epilepsy

@article{Dlugos2001ResponseTF,
  title={Response to first drug trial predicts outcome in childhood temporal lobe epilepsy},
  author={Dennis J. Dlugos and Mary D. Sammel and Brian L. Strom and John T Farrar},
  journal={Neurology},
  year={2001},
  volume={57},
  pages={2259 - 2264}
}
Objective: To construct a clinical prediction model for the early identification of children destined to develop refractory temporal lobe epilepsy (TLE) 2 years after epilepsy onset. Methods: Patients with TLE between 1 and 18 years old seen in the Division of Neurology at Children’s Hospital of Philadelphia during 1999 were identified through billing records and chart review. Data were abstracted independently on 5 candidate predictor variables for refractory TLE and on seizure frequency… 
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The data suggest that suitable patients failing two AED regimens should be referred for epilepsy surgery, and those who do not attain long‐term seizure freedom with the first three treatment schedules are likely to have refractory epilepsy.
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Intractable childhood epilepsy is expected if certain risk factors such as type, age of onset, gender and cause of epilepsy are found.
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Temporal lobe resection is effective in controlling medically intractable seizures, but there are potentially serious complications that need to be considered when counselling patients for such a procedure.
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Patients with vascular malformation and dual pathology as aetiology were most refractory, none being in remission for 12 months, but there were also patients achieving 12-month remission after a long period of active epilepsy.
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How reliable is early treatment response in predicting long-term seizure outcome?
  • D. Schmidt
  • Medicine, Psychology
    Epilepsy & Behavior
  • 2007
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