Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice.

@article{Heeckeren2006ResponseTA,
  title={Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice.},
  author={Anna M van Heeckeren and Mark D Schluchter and Wei Xue and Pamela B. Davis},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={173 3},
  pages={288-96}
}
RATIONALE Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator gene, which codes for a chloride channel, but the role of this chloride channel in inflammation induced by lung infection with Pseudomonas aeruginosa remains to be defined. OBJECTIVES We tested the hypothesis that loss of this chloride channel alone is sufficient to cause excessive inflammation in response to inflammatory stimuli. METHODS We investigated the response of cystic fibrosis… CONTINUE READING