Response to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcription.


In their commentary, Klyuyev and Vassylyev dispute a model of transcription inhibition by tagetitoxin (Tgt) proposed by us based on biochemical analysis and computational docking. We maintain that, although an alternative explanation can be provided for any single observation reported by us, taken together our results support a model in which Tgt acts by… (More)
DOI: 10.4161/trns.19749