Response to DNA damage of CHEK2 missense mutations in familial breast cancer.

@article{Roeb2012ResponseTD,
  title={Response to DNA damage of CHEK2 missense mutations in familial breast cancer.},
  author={Wendy Roeb and Jake Higgins and M. -T. King},
  journal={Human molecular genetics},
  year={2012},
  volume={21 12},
  pages={2738-44}
}
Comprehensive sequencing of tumor suppressor genes to evaluate inherited predisposition to cancer yields many individually rare missense alleles of unknown functional and clinical consequence. To address this problem for CHEK2 missense alleles, we developed a yeast-based assay to assess in vivo CHEK2-mediated response to DNA damage. Of 25 germline CHEK2… CONTINUE READING