Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis.

@article{Seddon2016ResponseTA,
  title={Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis.},
  author={Johanna M. Seddon and Rachel E. Silver and Bernard A Rosner},
  journal={The British journal of ophthalmology},
  year={2016},
  volume={100 12},
  pages={1731-1737}
}
BACKGROUND/AIMS The Age-Related Eye Disease Study (AREDS) reported the beneficial impact of antioxidant and zinc supplements on the risk of progression to advanced stages of age-related macular degeneration (AMD). We evaluated the role of genetic variants in modifying the relationship between supplementation and progression to advanced AMD. METHODS Among 4124 eyes (2317 subjects with a genetic specimen), 882 progressed from no AMD, early or intermediate AMD to overall advanced disease… CONTINUE READING
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