Response to 13 generations of selection for increased 8-week body weight in lines of mice carrying a sheep growth hormone-based transgene.

@article{Siewerdt2000ResponseT1,
  title={Response to 13 generations of selection for increased 8-week body weight in lines of mice carrying a sheep growth hormone-based transgene.},
  author={Frank Siewerdt and Eugene J. Eisen and James R D Murray and I J Parker},
  journal={Journal of animal science},
  year={2000},
  volume={78 4},
  pages={832-45}
}
The purpose of this study was to evaluate selection in lines of transgenic mice. Two replicates of lines that either carried or did not carry the sheep metallothionein-1a sheep growth hormone transgene (oMt1a-oGH) were established. The host lines had been previously selected for rapid growth or selected randomly. Within-litter selection for increased 8-wk body weight was carried out for 13 generations. The frequency of oMt1a-oGH was monitored in all generations in the transgenic lines, but no… CONTINUE READING