Response surface optimised extraction and chromatographic purification of rosmarinic acid from Melissa officinalis leaves

@inproceedings{Kim2010ResponseSO,
  title={Response surface optimised extraction and chromatographic purification of rosmarinic acid from Melissa officinalis leaves},
  author={Sooah Kim and Eun Ju Yun and Jin Seop Bak and Hojoung Lee and Sung-Joon Lee and Cheong Tae Kim and Jong hoon Lee and Kyoung Heon Kim},
  year={2010}
}
The extraction of lemon balm (Melissa officinalis) leaves with aqueous methanol was optimised using response surface methodology. Fifteen runs were conducted following a Box-Behnken design (BBD) followed by ridge analysis using the concentration of methanol, the extraction temperature and time as the independent variables and taking the extraction yield of RA from lemon balm as the response variable. The optimal extraction conditions were a methanol concentration of 59.0% (v/v), a temperature… CONTINUE READING

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