Response surface methodology for optimization of production of lovastatin by solid state fermentation

@inproceedings{Pansuriya2010ResponseSM,
  title={Response surface methodology for optimization of production of lovastatin by solid state fermentation},
  author={Ruchir C. Pansuriya and Rekha S. Singhal},
  booktitle={Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]},
  year={2010}
}
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by solid state fermentation (SSF) using a strain of Aspergillus terreus UV 1718. Different solid substrates and various combinations thereof were evaluated for lovastatin production. Wheat bran supported the maximum production (1458 ± 46 µg g(-1) DFM) of lovastatin. Response surface methodology (RSM) was applied to optimize the medium constituents. A 2(4) full-factorial central composite design (CCD) was chosen to explain the combined… CONTINUE READING
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