Response properties of the brainstem neurons of the cat following intra-esophageal acid–pepsin infusion

@article{Medda2005ResponsePO,
  title={Response properties of the brainstem neurons of the cat following intra-esophageal acid–pepsin infusion},
  author={Bidyut K. Medda and Jyoti N. Sengupta and Ivan M. Lang and Reza Shaker},
  journal={Neuroscience},
  year={2005},
  volume={135},
  pages={1285-1294}
}
Studies in humans have documented that acute acid infusion into the esophagus leads to decrease in threshold for sensations to mechanical distension of the esophagus. It is not known whether acid infusion leads to sensitization of brainstem neurons receiving synaptic input from vagal afferent fibers innervating the esophagus. The aim of this study was to investigate the correlation of responses of vagal afferents and brainstem neurons after acute infusion of acid (0.1 N HCl)+pepsin (1 mg/ml… CONTINUE READING

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