Response of the intact canine left ventricle to increased afterload and increased coronary perfusion pressure in the presence of coronary flow autoregulation.

@article{Karunanithi1999ResponseOT,
  title={Response of the intact canine left ventricle to increased afterload and increased coronary perfusion pressure in the presence of coronary flow autoregulation.},
  author={Mohanraj Karunanithi and Jennifer Young and W V Kalnins and Scott H. Kesteven and Michael P. Feneley},
  journal={Circulation},
  year={1999},
  volume={100 14},
  pages={1562-8}
}
BACKGROUND Increased left ventricular (LV) contractile force or oxygen consumption has been documented with increased coronary arterial pressure (CAP) and flow (Gregg phenomenon). We investigated whether the increase in contractile force with increased LV afterload might be mediated by the concomitant increase in CAP when coronary autoregulation is intact. METHODS AND RESULTS The LV of 6 autonomically blocked open-chest dogs was perfused through the left main coronary artery by a cannula with… CONTINUE READING
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