Response of the free alpha-subunit to GnRH distinguishes individuals with 'functional' from those with permanent hypogonadotropic hypogonadism.

Abstract

The aim of this study was to compare the responses of pituitary gonadotropins and the free alpha-subunit (FAS), measured by sensitive immunofluorometric assays at 0, 30 and 60 min after 100 microg GnRH i.v. in a group of 32 normal prepubertal boys (NB) and a group of 17 adult males with complete hypogonadotropic hypogonadism (HH). At time 0 min, medians of the serum levels of LH, FSH and FAS were not different in both groups. At 30 min (29.81 and 8.56 pmol/l) and 60 min (24.10 and 7.74 pmol/l) as well as peak levels (29.76 and 8.56 pmol/l), 'deltas' (peak minus baseline; 25.89 and 0.34 pmol/l) and 'fold'-increase (peak divided by baseline; 7.0-fold and 1. 6-fold), the medians were significantly higher in NB than in HH, respectively. There were fewer overlapping values of FAS between the 2 groups and they occurred in only 4% of the total number of subjects when 'fold' was considered. The measurement of FAS by a very sensitive immunofluorometric assay, after GnRH, distinguishes responses of NB from those of adult men with HH, that is of functional from permanent HH.

Cite this paper

@article{Mainieri1998ResponseOT, title={Response of the free alpha-subunit to GnRH distinguishes individuals with 'functional' from those with permanent hypogonadotropic hypogonadism.}, author={Alberto Scofano Mainieri and Julio Viera and Regina Helena Elnecave}, journal={Hormone research}, year={1998}, volume={50 4}, pages={212-6} }