Response of the exocrine pancreas to graded doses of secretin in calcium-treated and normal dogs

@article{NoelJorand1981ResponseOT,
  title={Response of the exocrine pancreas to graded doses of secretin in calcium-treated and normal dogs},
  author={M. Noel-Jorand and D. Schmidt and M. Devaux and H. Sarles},
  journal={Regulatory Peptides},
  year={1981},
  volume={2},
  pages={181-191}
}
Persisting modifications induced by repeated intravenous calcium infusion (acute hypercalcaemia) were investigated in 6 Thomas fistula dogs: 4 controls and 4 calcium-treated dogs, two of which were studied as controls. (a) The pancreatic response to graded doses of synthetic secretin (water and bicarbonate outputs) was significantly reduced in calcium-treated dogs when compared with controls. As both the D50 for secretin-induced response increased, and the maximal secretory response decreased… Expand
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