Response of the cell membrane-cytoskeleton complex to osmotic and freeze/thaw stresses.

@article{Ragoonanan2010ResponseOT,
  title={Response of the cell membrane-cytoskeleton complex to osmotic and freeze/thaw stresses.},
  author={Vishard Ragoonanan and Allison Hubel and Alptekin Aksan},
  journal={Cryobiology},
  year={2010},
  volume={61 3},
  pages={335-44}
}
In order to develop successful cryopreservation protocols a better understanding of the freeze- and dehydration-induced changes occurring in the cell membrane and its underlying support, the actin cytoskeleton, is required. In this study, we compared the biophysical response of model mammalian cells (human foreskin fibroblasts) to hyperosmotic stress and freeze/thaw. Transmitted light, infrared spectroscopy, fluorescence- and cryo-microscopy were used to investigate the changes in the cell… CONTINUE READING

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