Corpus ID: 709581

Response of the atrial pacemaker to dobutamine.

  title={Response of the atrial pacemaker to dobutamine.},
  author={L. E. Puntoni de Mikuli{\'c} and M. T. M{\'a}rquez and P. Aramend{\'i}a},
  journal={Acta physiologica latino americana},
  volume={27 3},
  • L. E. Puntoni de Mikulić, M. T. Márquez, P. Aramendía
  • Published 1977
  • Medicine
  • Acta physiologica latino americana
  • The action of dobutamine, (+/-)-4- [2- [[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl] pyrocatechol hydrochloride was studied on the pacemaker of the isolated rat atria. The dose-chronotropic response curve showed a typical bell-dome shape of the sympathomimetic amines. Reserpinization of the animals did not change the curve of the agonist. Cocaine (6.7 microgram/ml) induced a decrease of the sensitivity of the rat atria pacemaker for dobutamine (p less than 0.001). Propranolol (3 X 10(-8… CONTINUE READING