Response of the IGF-I system to prolonged undernutrition and its involvement in somatic and skeletal muscle growth retardation in rats.

@article{Gautsch1998ResponseOT,
  title={Response of the IGF-I system to prolonged undernutrition and its involvement in somatic and skeletal muscle growth retardation in rats.},
  author={T A Gautsch and Susanne Kandl and Sharon M Donovan and Donald K Layman},
  journal={Growth, development, and aging : GDA},
  year={1998},
  volume={62 1-2},
  pages={13-25}
}
We examined the response of the IGF-I system to prolonged undernutrition and its involvement in somatic and skeletal muscle growth retardation. Male rats were food-restricted to 50% of freely-fed controls (C) from birth to 120 days postpartum. Serum and tissues were collected at d 50 and d 120 postpartum. Somatic growth of food-restricted animals (R) was proportional to food intake while organ and tissue growth was disproportionate. Skeletal muscle DNA content and synthesis rates were depressed… CONTINUE READING

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