Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role

@inproceedings{Koizumi2013ResponseOS,
  title={Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role},
  author={Hidetaka Koizumi and Ryoma Morigaki and Shinya Okita and Shinji Nagahiro and Ryuji Kaji and Masanori Nakagawa and Satoshi Goto},
  booktitle={Front. Cell. Neurosci.},
  year={2013}
}
The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification (TSA) protocols to determine the distributional patterns of opioid receptors in the… CONTINUE READING
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