Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development.

@article{WrayCahen1998ResponseOS,
  title={Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development.},
  author={Diane Wray-Cahen and Hanh V. Nguyen and Douglas Burrin and Philip R Beckett and Marta L Fiorotto and Peter J. Reeds and Timothy J Wester and Teresa A Davis},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1998},
  volume={275 4},
  pages={E602-E609}
}
The elevated rate of muscle protein deposition in the neonate is largely due to an enhanced stimulation of skeletal muscle protein synthesis by feeding. To examine the role of insulin in this response, hyperinsulinemic-euglycemic-amino acid clamps were performed in 7- and 26-day-old pigs. Pigs were infused with 0, 30, 100, or 1,000 ng ⋅ kg-0.66 ⋅ min-1of insulin to mimic the plasma insulin levels observed under fasted, fed, refed, and supraphysiological conditions, respectively. Whole body… CONTINUE READING

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