Response of rat lung to tobacco smoke condensate or fractions derived from it administered repeatedly by intratracheal instillation.

@article{Davis1975ResponseOR,
  title={Response of rat lung to tobacco smoke condensate or fractions derived from it administered repeatedly by intratracheal instillation.},
  author={Barry R. Davis and Jie Kah Whitehead and M. K. Gill and Prof Mark Lee and A. D. Butterworth and Francis J. C. Roe},
  journal={British Journal of Cancer},
  year={1975},
  volume={31},
  pages={453 - 461}
}
The repeated intratracheal instillation of cigarette smoke condensate (SWS) in rats at close to maximum tolerated dose levels failed to induce squamous neoplasms in the lungs although such treatment was associated with an increased incidence of cuboidal/columnar metaplasia (CCM) and squamous metaplasia (Sq.M) of alveolar epithelium. With one exception, various fractions of SWS had no effect on lung tumour incidence though some were more effective than SWS in increasing the incidence of CCM and… CONTINUE READING

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