Response of purified chick motoneurons to myotube conditioned medium: laminin is essential for the substratum-binding, neurite outgrowth-promoting activity.


Purified motoneurons from chick, cultured on polycationic substrata treated with myotube-conditioned (MCM), respond by rapidly extending neurites. When MCM, partially purified by salt precipitation and ion-exchange chromatography, was fractionated on Sepharose CL-4B, the peak of neurite outgrowth-promoting activity (NOPA) corresponded to a peak of laminin… (More)


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