Response of protein synthesis to anoxia and recovery in anoxia-tolerant hepatocytes.

@article{Land1993ResponseOP,
  title={Response of protein synthesis to anoxia and recovery in anoxia-tolerant hepatocytes.},
  author={Stephen C. Land and Leslie Thomas Buck and Peter W. Hochachka},
  journal={The American journal of physiology},
  year={1993},
  volume={265 1 Pt 2},
  pages={R41-8}
}
Hepatocytes from the western painted turtle (Chrysemys picta bellii) display a profound metabolic suppression under anoxia. Fractional rates of protein synthesis fell by 92% during 12 h anoxia at 25 degrees C and were indistinguishable from the rate obtained with cycloheximide. Normoxic recovery saw protein synthesis increase to 160% of control values and return to normal after 2 h. The GTP-to-GDP ratio, implicated in the control of translation, fell threefold during anoxia. Purine nucleotide… CONTINUE READING

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