Response of neutrophils to stimulus infusion: differential sensitivity of cytoskeletal activation and oxidant production

@article{Omann1988ResponseON,
  title={Response of neutrophils to stimulus infusion: differential sensitivity of cytoskeletal activation and oxidant production},
  author={Geneva M. Omann and Larry A. Sklar},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={107},
  pages={951 - 958}
}
The response of human neutrophils to N-formyl peptides were studied under conditions where ligand binding was controlled by infusing a cell suspension with the peptide over a time period comparable to the normal half-time for binding. Receptor occupancy was measured in real time with a fluorescently labeled peptide using flow cytometry. This binding was approximated by a simple reversible model using typical on (7 X 10(8) M- min-1) and off (0.35/min) rate constants and the infusion rates (0.02… CONTINUE READING
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Transient rise in lysophosphoinositides concomitant with neutrophil activation

  • A. E. Traynor-Kaplan, A. L. Harris, G. M. Omann, J. E. Smolen, L. A. Sklar
  • 1987

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