Response of malignant and nonmalignant epidermal cell lines to tunicamycin

  title={Response of malignant and nonmalignant epidermal cell lines to tunicamycin},
  author={M. Brysk and J. Miller and S. Chen and P. C. Moller and R. W. Stach},
  journal={Cell and Tissue Research},
  • M. Brysk, J. Miller, +2 authors R. W. Stach
  • Published 2004
  • Biology, Medicine
  • Cell and Tissue Research
  • SummaryExposure of fibroblasts to tunicamycin has been found to be cytotoxic for transformed cells, but not for nontransformed cells. With two mouse epidermal cell lines of common origin, we observe a contrary pattern: The malignant cells are more resistant to tunicamycin than their nonmalignant counterparts, as measured by growth and viability. With respect to the glycosylation of sugar precursors, the incorporation of mannose is more inhibited than that of glucosamine, while fucose is least… CONTINUE READING

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