Response of isolated hepatocytes to organic and inorganic cytotoxins.

Abstract

Thirty-four chemicals-diverse in structure, postulated mechanisms of action, and primary target organs--were tested for cytotoxic response in isolated hepatocyte suspensions from young male Sprague-Dawley rats. Hepatocytes were incubated in the presence and absence of the test chemicals in closed vessels fitted with side arms for serial sampling for up to 5… (More)

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