Response of intraventricular macrophages after a penetrant cerebral lesion.


The response of epiplexus and supraependymal cells to extravasated blood after a penetrant cerebral lesion was investigated. Epiplexus cells respond more actively than supraependymal cells. The epiplexus cells tend to aggregate near areas of extravasation of erythrocytes, this being most marked 6 hours after injury. Epiplexus cells lose their smooth surface appearance, retract their filopodia and adopt a more spherical form, with short microvilli or blebs. Numerous inclusion vesicles develop; some contain disrupted erythrocytes 6-12 hours after injury and these are still present 24-30 hours after injury. By 8-16 days after injury epiplexus cells resume a smooth surface appearance and the number of inclusion vesicles is much reduced. This suggests reversion to a quiescent state, from an earlier active state.


Citations per Year

933 Citations

Semantic Scholar estimates that this publication has 933 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Maxwell1988ResponseOI, title={Response of intraventricular macrophages after a penetrant cerebral lesion.}, author={William L. Maxwell and James McGadey}, journal={Journal of anatomy}, year={1988}, volume={160}, pages={145-55} }