Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.

@article{Guillot2004ResponseOH,
  title={Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.},
  author={Lo{\"i}c Guillot and Samir Medjane and Karine Le-Barillec and Viviane Balloy and Claire Danel and Michel Chignard and Mustapha Si-Tahar},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 4},
  pages={2712-8}
}
Pulmonary epithelial cells are continuously exposed to microbial challenges as a result of breathing. It is recognized that immune myeloid cells express Toll-like receptors (TLRs), which play a major role in detecting microbes and initiating innate immune responses. In contrast, little is known concerning the expression of TLR in pulmonary epithelial cells per se, their distribution within the cell, their function, and the signaling pathways involved. In this work, we demonstrated by reverse… CONTINUE READING
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