Response of human fibroblasts to tantalum and titanium in cell culture.

@article{Mostardi1997ResponseOH,
  title={Response of human fibroblasts to tantalum and titanium in cell culture.},
  author={Richard A Mostardi and Sharon O Meerbaum and Mark W Kovacik and Ivan Gradisar},
  journal={Biomedical sciences instrumentation},
  year={1997},
  volume={33},
  pages={514-8}
}
The loosening of total joint arthroplasties (TKA) with associated osteolysis has been a persistent problem in orthopaedics. Wear debris from prosthetic devices including Titanium (Ti) is involved in this process. Mechanisms for this osteolytic process are unclear. The purpose of this study was to compare the biological response of Ti and Tantalum (Ta) on retrieved human fibroblasts. Fibroblasts were retrieved from human volunteers and cultured using standard techniques. Twenty-five (25) ml… CONTINUE READING