Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation

@article{vonHeyden1995ResponseOG,
  title={Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation},
  author={Burkhard von Heyden and Robert Kirk Riemer and Lora S. Nunes and Gerald B. Brock and Tom F Lue and Emil A. Tanagho},
  journal={Neurourology and Urodynamics},
  year={1995},
  volume={14}
}
Prazosin (an alpha‐1‐adrenergic blocker) and cromakalim (potassium channel opener), given alone, induced significant fatigue of the urethral sphincter at a concentration of 10−4 M; both drugs combined achieved a significant sphincteric fatigue at a concentration of 10−5 M each. To 10−4 M hexamethonium (ganglionic smooth muscle blocker) and 10−4 M decamethonium (nicotinic blocker of striated muscle) the striated urethral sphincter responded like striated muscle with no detectable function of its… 

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