Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

@article{Bessou1969ResponseOC,
  title={Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.},
  author={Paul Bessou and Edward R. Perl},
  journal={Journal of neurophysiology},
  year={1969},
  volume={32 6},
  pages={
          1025-43
        }
}
the concept that sense organs of the skin with unmyelinated (C) fibers have widely varying functional characteristics. In the mammal, a large proportion of such sensory units are excited by gentle mechanical stimuli (8, 16, 34) and by transient cooling (9). Others are described as responding best to small temperature changes (13, 18) and some are reported to have elevated thresholds for various or all stimuli (14, 15, 18, 32). Studies proposing large and important differences between various… 

Cutaneous Mechanoreceptors and Nociceptors

Although information from sense organs is used by all animals, only man can verbally report his sensory experience, and neurophysiological experiments defining the properties of cutaneous sense organs have most often been done on animals other than man.

Novel classes of responsive and unresponsive C nociceptors in human skin

Novel classes of C nociceptors in human skin are reported, namely, units responding only to mechanical stimuli (CM), units respondingonly to heating (CH), and units that were insensitive to mechanical and heating stimuli and also to sympathetic provocation tests (CMiHi).

Afferent activity in thin myelinated and unmyelinated cutaneous nerve fibers during mechanical stimulation of skin receptors

Afferent activity in thin myelinated and unmyelinated cutaneous nerve fibers was analyzed by an impulse collision method and by methods improving the signal-to-noise ratio in the record of the

The Classification and Properties of Nociceptive Afferent Units from the Skin of the Anaesthetized Pig

The afferent properties of nerve fibres innervating the hairy skin of the pig hind limb were investigated by recording from 142 single units from the saphenous nerve using maximal electrical stimulation of the nerve trunk to identify the heat‐sensitive mechanoreceptors and the lack of heat sensitization in C‐polymodal nociceptors from hairy skin.

Specific C-Receptors for Itch in Human Skin

It is concluded that these C-fibers represent a new class of afferent nerve fibers with particularly thin axons but excessive terminal branching, which probably represents the afferent units long searched for mediating itch sensations.

Responses of cutaneous A-fiber nociceptors to noxious cold.

It is concluded that the proportion of cutaneous A delta-nociceptors excited by noxious cold stimuli has been underestimated in previous studies and is likely to contribute to the sensation of cold pain, particularly pain produced by stimulus temperatures <0 degrees C.
...

References

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The present experiments were done to learn more of the sensory functions of the non-myelinated afferent fibres in cutaneous nerves by studying their electrical activity and examining whether or not they signal changes in skin temperature.

The specificity of afferent cutaneous C fibres in mammals.

The skin of the mammals investigated thus possess specific “warm” C fibres as well as specific ‘cold’ C fibre which are reciprocally brought in and out of action when the skin is subjected to even slight temperature changes.

Relation of peripheral nerve fiber size and sensation in man.

This study of human responses to electrographically monitored activation of selected portions of the peripheral nerve fiber sizespectrum sought to determine whether a relationship between fiber and sensation was found.

Touch, pain and tickling: an electro‐physiological investigation on cutaneous sensory nerves

The present research was started in order to study the response of the thinnest afferent fibres to various stimuli applied to the skin to provide some fixed points for the correlation of results from different experiments.

Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli

  • E. Perl
  • Biology
    The Journal of physiology
  • 1968
1. The functional characteristics of cutaneous receptors in the squirrel monkey were determined by recording discharges of single myelinated afferent fibres in peripheral nerves with micro‐electrodes

EXPERIMENTS ON HISTAMINE AS THE CHEMICAL MEDIATOR FOR CUTANEOUS PAIN

Experimental evidence shows that histamine is liberated when the upper layers of the skin are stimulated in the threshold range although no gross or microscopic evidence of tissue damage is

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Electrophysiological recordings made from single nerve fibers which were specifically responsive to temperature changes of the skin of monkeys found that the activity in a single thermally sensitive fiber increased when any one of eight individual spots on the skin was cooled.

Myelinated afferent fibres responding specifically to noxious stimulation of the skin

1. The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes. The distinctive features of 513

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The functions of the Brain and the Theories of their Relation are studied in detail in the second volume of Nick Wade's Mind and Body, which aims to clarify the role of the nervous system in human health.

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A spike separation technique which combines data processing methods with extracellular probing techniques to allow simultaneous observation of multiple neural events is presented and experimental results and simulation indicate the usefulness of the method.