Response of compressed skinned skeletal muscle fibers to conditions that simulate fatigue.

@article{Myburgh1997ResponseOC,
  title={Response of compressed skinned skeletal muscle fibers to conditions that simulate fatigue.},
  author={Kathryn Helen Myburgh and Roger Cooke},
  journal={Journal of applied physiology},
  year={1997},
  volume={82 4},
  pages={1297-304}
}
During fatigue, muscles become weaker, slower, and more economical at producing tension. Studies of skinned muscle fibers can explain some but not all of these effects, and, in particular, they are less economical in conditions that simulate fatigue. We investigated three factors that may contribute to the different behavior of skinned fibers. 1) Skinned fibers have increased myofilament lattice spacing, which is reversible by osmotic compression. 2) A myosin subunit becomes phosphorylated… CONTINUE READING

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1 Excerpt

The role of intracellular acidosis in muscle fatigue

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