Response of cluster headache to psilocybin and LSD

@article{Sewell2006ResponseOC,
  title={Response of cluster headache to psilocybin and LSD},
  author={R Andrew Sewell and John H. Halpern and Harrison G Pope},
  journal={Neurology},
  year={2006},
  volume={66},
  pages={1920 - 1922}
}
The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted. 

Tables from this paper

Psychedelic and nonpsychedelic LSD and psilocybin for cluster headache
  • W. Davenport
  • Psychology, Medicine
    Canadian Medical Association Journal
  • 2016
TLDR
Clinicians have an interest in extending research into headache medicine, especially the treatment of cluster headaches when episodes are cluster headaches, Upper and colleagues suggest.
silocybin dose-dependently causes delayed , transient headaches in healthy olunteers atthew
TLDR
This double-blind study examined a broad range of psilocybin doses on headache in 18 healthy participants and found that p silocybin frequently caused headache, the incidence, duration, and severity of which increased in a dose-dependent manner.
Lysergic acid diethylamide and psilocybin for the management of patients with persistent pain: a potential role?
TLDR
LSD and psilocybin are generally safe if administered by a healthcare professional, although further investigations are needed to assess their utility for patients with persistent pain, especially associated with terminal illness.
A case of cluster headache treated with rotigotine: Clinical and neurophysiological correlates
TLDR
It is suggested that rotigotine could represent a further therapeutic option in the treatment of drug-resistant CCH by improving the nociceptive blink reflex habituation in a 43-year-old male patient with treatment- resistant CCH.
Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers.
Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey
TLDR
Findings provide additional evidence that several indoleamine hallucinogens are rated as effective in treating cluster headache and reinforce the need for further investigation of the effects of these and related compounds in cluster headache under experimentally controlled settings.
Serotonergic Agents in the Management of Cluster Headache
TLDR
The current knowledge about serotonergic agonists and antagonists used in the management of cluster headache is reviewed, focusing on their mechanisms of action and on the possible role of serotonin system dysfunction in this complex disorder.
Drug and Alcohol Dependence
TLDR
Headache is an adverse event to be expected with the nonmedical use of psilocybin-containing mushrooms as well as the administration of p silocybin in human research, and should not present a barrier to future pSilocybin research.
Licit and Illicit Drug Use in Cluster Headache
TLDR
The licit drugs were included in this review because their use seems to be driven by the same addiction mechanisms leading to illicit drug abuse, and the dopaminergic and orexinergic pathways could be targeted for future studies.
Increased use of illicit drugs in a Dutch cluster headache population
TLDR
In the Netherlands, people with cluster headache use illicit drugs more often than the general population, and the question remains whether this is due to an actual alleviatory effect, placebo response, conviction, or common pathophysiological background between cluster headache and addictive behaviours such as drug use.
...
...

References

SHOWING 1-10 OF 12 REFERENCES
A Double-Blind Placebo-Controlled Trial of Intranasal Capsaicin for Cluster Headache
TLDR
Results indicate that intranasal capsaicin may provide a new therapeutic option for the treatment of this disease and Episodic CH patients appeared to benefit more than chronic CH patients.
Verapamil in the prophylaxis of episodic cluster headache: A double-blind study versus placebo
TLDR
A significant reduction in attack frequency and abortive agents consumption in the verapamil group and objective evidence for the effectiveness of verAPamil in episodic cluster headache prophylaxis is provided.
Melatonin Versus Placebo in the Prophylaxis of Cluster Headache
TLDR
Although the response rate is low, melatonin may be suitable for cluster headache prophylaxis in some patients, particularly those who cannot tolerate other drugs.
[Cluster headache].
  • Y. Takase
  • Medicine
    Nihon rinsho. Japanese journal of clinical medicine
  • 2005
Cluster headaches are characterized by attacks of strictly unilateral severe pain which is orbital, supraorbital, temporal or in any combination of these sites associated with one or more of the
Some Remarks on the Terminology of Cluster Headache
  • K. Ekbom
  • Medicine, Psychology
    Cephalalgia : an international journal of headache
  • 1988
TLDR
It is important to use uniform nomenclature based on semiologically precise definitions to denote basic clinical concepts integral to the cluster headache syndrome.
Intranasal sumatriptan in cluster headache
TLDR
Sumatriptan nasal spray is effective and well tolerated in the acute treatment of cluster headache attacks of at least 45 minutes’ duration and was also superior to placebo considering initial response, meaningful relief, and relief of associated symptoms.
The International Classification of Headache Disorders
TLDR
The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed.
Suppression of Pain and the R2 Component of the Blink Reflex During Optokinetic Stimulation
  • P. Drummond
  • Biology, Psychology
    Cephalalgia : an international journal of headache
  • 2004
TLDR
It is suggested that a mechanism that suppresses symptoms of motion sickness during sensory conflict also inhibits activity in wide dynamic range neurones in the trigeminal nucleus caudalis.
A comparison of cigarette smokers recruited through the Internet or by mail.
TLDR
Smokers self-recruited through the Internet were younger, more educated, more motivated to quit smoking and smoked more cigarettes per day than smokers in the other samples.
double-blind pilot study with parallel groups. Cephalalgia
  • 1996
...
...