Response of children with stage IV soft tissue sarcoma to topotecan and carboplatin: a phase II window trial of the cooperative soft tissue sarcoma group.

@article{Bochennek2013ResponseOC,
  title={Response of children with stage IV soft tissue sarcoma to topotecan and carboplatin: a phase II window trial of the cooperative soft tissue sarcoma group.},
  author={Konrad Bochennek and Tobias M Dantonello and Ewa B Koscielniak and Alexander Claviez and Uta Dirksen and A. Sauerbrey and Andreas Beilken and Thomas Klingebiel},
  journal={Klinische Padiatrie},
  year={2013},
  volume={225 6},
  pages={309-14}
}
To investigate antitumor activity and toxicity associated with combined topotecan and carboplatin treatment in children and adolescents with metastasized, untreated soft tissue sarcoma (STS).Patients (n=34) less than 21 years old and untreated, stage IV STS. Patients were treated with topotecan (1 mg/m²/d for 4 days) and carboplatin (150 mg/m²/d for 4 days) (TC course) during week 1 and 4 of a chemotherapy window trial, which was followed by chemotherapy and local therapy from week 6 on. We… CONTINUE READING