Response of carcinogen-altered mouse epidermal cells to phorbol ester tumor promoters and calcium.

@article{Hennings1987ResponseOC,
  title={Response of carcinogen-altered mouse epidermal cells to phorbol ester tumor promoters and calcium.},
  author={Henry Hennings and Dagmar Michael and Ulrike F. Lichti and Stuart H. Yuspa},
  journal={The Journal of investigative dermatology},
  year={1987},
  volume={88 1},
  pages={60-5}
}
Primary cultures of mouse epidermal cells are induced to terminally differentiate when extracellular calcium levels are increased to more than 0.1 mM. After carcinogen treatment, cellular foci can be selected that resist this calcium signal to terminally differentiate. Calcium causes these foci to stratify; however, in contrast to normal epidermis, DNA-synthesizing cells in these foci are found in the suprabasal cell layers as well as in basal cells. Cell lines derived from these foci may be… CONTINUE READING
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