Response of brain tissue to chronically implanted neural electrodes

  title={Response of brain tissue to chronically implanted neural electrodes},
  author={Vadim S. Polikov and Patrick A. Tresco and William M. Reichert},
  journal={Journal of Neuroscience Methods},

Figures from this paper

Chronically Implanted Intracranial Electrodes: Tissue Reaction and Electrical Changes

The tissue response to electrode implantation on acute and chronic timescales, the electrical changes that occur in electrode systems over time, and strategies that are being investigated in order to minimize the tissueresponse to implantation and maximize functional electrode longevity are discussed.

The Active Electrode in the Living Brain: The Response of the Brain Parenchyma to Chronically Implanted Deep Brain Stimulation Electrodes.

Establishing how stimulation influences the electrical and histological properties of the surrounding tissue is critical in understanding how these factors contribute to DBS efficacy, and in controlling symptoms and side effects.

Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

The feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode) is demonstrated and neural recordings in freely moving sheep for up to 190 d are demonstrated.

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

The development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel elicits responses from specific facial muscles and limbs in sheep.

Effects of Glial Cells on Electrode Impedance Recorded from Neural Prosthetic Devices In Vitro

An in vitro system in which cell conditions can be varied within an artificial tissue matrix surrounding a neural prosthetic device is designed in which the effects of glial cell type on electrode impedance to be determined.

Explant Analysis of Utah Electrode Arrays Implanted in Human Cortex for Brain-Computer-Interfaces

Both tissue encapsulation and material degradation were more pronounced in the arrays that were implanted for a longer duration, and these arrays also had lower signal amplitude and impedance.

The glia-neuronal response to cortical electrodes: Interactions with substrate stiffness and electrophysiology

The tissue response and its effect on electrode recordings is investigated, and a mechanically adaptive nanocomposite is examined that is stiff enough for insertion, but softer than traditional BMI electrodes after brain implantation.

Optimizing the neuron-electrode interface for chronic bioelectronic interfacing.

  • Conor Keogh
  • Materials Science, Biology
    Neurosurgical focus
  • 2020
Optimization of the neuron-electrode interface allows the use of long-term, high-resolution stimulation and recording, opening the door to responsive closed-loop systems with highly selective modulation.

Physiological Challenges for Intracortical Electrodes

Electrode Failure: Tissue, Electrical, and Material Responses

The development of invasive, rehabilitative neuroprosthetics for humans requires reliable neural probes that are capable of recording large ensembles of neurons for a long period of time and suffers from time-dependent degradation in signal quality due to unknown issues related to tissue interfaces.



Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex

Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes.

The results indicate that, after implantation, the electrode-tissue interface may change from day-to-day over the first 1-2 weeks, week- to-week for 1- 2 months, and become quite stable thereafter, and a stability index is proposed to quantify the stability of the electrodes-tissues interface.

Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex.

Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex

This study investigated the use of planar, silicon-substrate microelectrodes for chronic unit recording in the cerebral cortex and provided a performance baseline to support further electrode system development for intracortical neural implant systems for medical applications.

The cone electrode: a long-term electrode that records from neurites grown onto its recording surface

  • P. Kennedy
  • Biology
    Journal of Neuroscience Methods
  • 1989

Multiple single-unit recordings from the CNS using thin-film electrode arrays

The feasibility of using thin-film recording arrays (multisite microprobes) to record cortical activity on a long-term basis has been assessed, using an in vitro turtle preparation and the

Ceramic-based multisite electrode arrays for chronic single-neuron recording

These arrays were capable of recording single neuron activity from each of their recording sites for at least three weeks during chronic implantation in the somatosensory cortex of rats, and several sites had recordings that lasted for more than 8 weeks.

Techniques for long-term multisite neuronal ensemble recordings in behaving animals.

A series of methodological developments aimed at enhancing the power of the methods needed to record simultaneously from populations of neurons over broad regions of the brain in awake, behaving animals are described.

Cerebral Astrocyte Response to Micromachined Silicon Implants

It was concluded that reactive gliosis is an important part of the process forming the cellular sheath, at least partially composed of reactive glia, which isolates the probe from the brain.