Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets: comparison of pH-stat and alpha-stat strategies.

@article{Markowitz2007ResponseOB,
  title={Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets: comparison of pH-stat and alpha-stat strategies.},
  author={Scott D. Markowitz and Alberto Mendoza-Paredes and Huiping Liu and Peter Pastuszko and Steven Peter Schultz and Gregory J. Schears and William J. Greeley and David F Wilson and Anna Pastuszko},
  journal={The Annals of thoracic surgery},
  year={2007},
  volume={84 1},
  pages={
          170-6
        }
}
BACKGROUND To determine the effect of pH-stat as compared with alpha-stat management on brain oxygenation, level of striatal extracellular dopamine, phosphorylation, and levels of protein kinase B (Akt) and cyclic adenosine 3', 5'-monophosphate response element-binding protein (CREB), and levels of extracellular signal-regulated kinase (ERK)1/2, Bcl-2, and Bax in a piglet model of deep hypothermic circulatory arrest (DHCA). METHODS The piglets were placed on cardiopulmonary bypass (CPB… CONTINUE READING
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Effect of deep hypothermic circulatory arrest followed by low-flow cardiopulmonary bypass on brain metabolism in newborn piglets: comparison of pH-stat and α-stat management.

  • Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2011
VIEW 2 EXCERPTS
CITES RESULTS & METHODS

Acid-base management and temperature control during hypothermic circulatory arrest.

  • Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • 2009

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