Response of alveolar macrophages to in vitro exposure to freshly fractured versus aged silica dust: the ability of Prosil 28, an organosilane material, to coat silica and reduce its biological reactivity.

@article{Vallyathan1991ResponseOA,
  title={Response of alveolar macrophages to in vitro exposure to freshly fractured versus aged silica dust: the ability of Prosil 28, an organosilane material, to coat silica and reduce its biological reactivity.},
  author={Val Vallyathan and Jung Hun Kang and Knox Van Dyke and Nar S. Dalal and Vincent Castranova},
  journal={Journal of toxicology and environmental health},
  year={1991},
  volume={33 3},
  pages={303-15}
}
We have reported previously that crushing or grinding crystalline silica results in the generation of silica-based radicals on the particulate surface and that these radicals can generate hydroxyl radicals in aqueous solution. Data in the present study indicate that freshly ground silica is more cytotoxic and is a more potent activator of alveolar macrophages than comparably sized aged silica. That is, compared to aged silica, fresh silica is 4.2-fold more potent in decreasing the membrane… CONTINUE READING

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