Response of Hypothalamo-pituitary-adrenal Axis and Immune System to Chronic Restraint Stress in Male Sprague Dawley Rats


Background: During stress, hypothalamic pituitary adrenal axis (HPA) is activated as an adaptive ‘fight or flight’ response in order to maintain homeostasis of body function and alter immune response. Method: This study was conducted at National Institute of Health (NIH) Islamabad. Sixty healthy male Sprague Dawley rats (age=65±5 days; weight=250±50 gm… (More)


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