Response of Drosophila to Wasabi Is Mediated by painless, the Fly Homolog of Mammalian TRPA1/ANKTM1

@article{AlAnzi2006ResponseOD,
  title={Response of Drosophila to Wasabi Is Mediated by painless, the Fly Homolog of Mammalian TRPA1/ANKTM1},
  author={Bader S Al-Anzi and W. D. Tracey and Seymour Benzer},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1034-1040}
}
A number of repellent compounds produced by plants elicit a spicy or pungent sensation in mammals . In several cases, this has been found to occur through activation of ion channels in the transient receptor potential (TRP) family . We report that isothiocyanate (ITC), the pungent ingredient of wasabi, is a repellent to the insect Drosophila melanogaster, and that the painless gene, previously known to be required for larval nociception, is required for this avoidance behavior. A painless… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Taste Perception and Coding in Drosophila
BACKGROUND Discrimination between edible and contaminated foods is crucial for the survival of animals. In Drosophila, a family of gustatory receptors (GRs) expressed in taste neurons is thought toExpand
painless, a Drosophila Gene Essential for Nociception
TLDR
In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe, and a genetic screen for mutants defective in this noxious heat response was identified, identifying the painless gene. Expand
Gustatory organs of Drosophila melanogaster: fine structure and expression of the putative odorant-binding protein PBPRP2
TLDR
In the taste bristles of the labellum and legs, PBPRP2 is localized in the crescent-shaped lumen of the sensilla, and not in the lumen where the dendrites of the gustatory neurons are found, making a function in stimulus transport unlikely in these sensilla. Expand
Molecular neurophysiology of taste in Drosophila
TLDR
It is found that particular tarsal gustatory sensilla respond to bitter compounds, and determination of the molecular bases for this heterogeneity could lead to an understanding of how the sensory information is processed in the brain and how this in turn is linked to behavior. Expand
A capsaicin-receptor homologue with a high threshold for noxious heat
TLDR
It is proposed that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities. Expand
Genetic analysis of a complex chemoreceptor.
TLDR
Taste responses of Dipterans have been extensively investigated for more than three decades and it is evident that taste discrimination in insects, as in mammals, is based upon a small set of categoric distinctions, but the exact nature of the sensory code remains unknown. Expand
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
TLDR
The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8. Expand
Neurobiology of the gustatory systems of Drosophila and some terrestrial insects
  • R. Singh
  • Biology, Medicine
  • Microscopy research and technique
  • 1997
TLDR
The understanding of basic mechanisms of taste perception in insects is likely to lead to better management of useful as well as harmful insects. Expand
Imaging Taste Responses in the Fly Brain Reveals a Functional Map of Taste Category and Behavior
TLDR
These studies reveal that Gr5a cells selectively respond to sugars and Gr66a cells to bitter compounds and demonstrate that taste cells are tuned by taste category and are hardwired to taste behaviors. Expand
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
TLDR
It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana. Expand
...
1
2
3
...