Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits.

@article{Rosenberg1997ResponseinhibitionDI,
  title={Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits.},
  author={David R. Rosenberg and Eduardo Dick and Kirsten M O'Hearn and John A. Sweeney},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={1997},
  volume={22 1},
  pages={
          29-38
        }
}
Abnormalities in the orbital prefrontal cortex and its ventral striatal target fields are believed to be involved in causing obsessive and compulsive symptoms. Lesions to this brain circuitry result in a selective disturbance in suppressing responses to irrelevant stimuli. This disturbance might underlie the apparent inhibitory deficit suggested by the symptomatology of obsessive-compulsive disorder (OCD). Oculomotor tests were administered to 12 medication-free, nondepressed patients with OCD… CONTINUE READING
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