Response in hepatic removal of amino acids by the sheep to short-term infusions of varied amounts of an amino acid mixture into the mesenteric vein.

@article{Lobley2001ResponseIH,
  title={Response in hepatic removal of amino acids by the sheep to short-term infusions of varied amounts of an amino acid mixture into the mesenteric vein.},
  author={Gerald E. Lobley and David M. Bremner and David Spaulding Brown},
  journal={The British journal of nutrition},
  year={2001},
  volume={85 6},
  pages={689-98}
}
Under conditions of chronic supply the liver removes most amino acids (AA) in excess of net anabolic needs. Little information is available, however, on how acute alterations in AA supply (as might occur with once-daily feeding regimens) are controlled by the liver. Are these also extracted completely in a 'first-pass' manner or are there limitations to hepatic uptake? Furthermore, is the rate of removal 'saturable' (by Michaelis-Menten kinetics) over the range of supply experienced under… CONTINUE READING

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