Response and resistance to BET bromodomain inhibitors in triple negative breast cancer

  title={Response and resistance to BET bromodomain inhibitors in triple negative breast cancer},
  author={Shaokun Shu and Charles Y. Lin and Housheng Hansen He and Robert M. Witwicki and Doris P. Tabassum and Justin M Roberts and Michalina Janiszewska and Sung Jin Huh and Yi Liang and Jeremy A Ryan and Ernest Doherty and Hisham Mohammed and Hao Guo and Daniel G Stover and Muhammad B. Ekram and Jonathan D Brown and Clive S D'Santos and Ian Krop and Deborah A. R. Dillon and Michael R. McKeown and Christopher J. Ott and Jun Qi and Min Ni and Prakash K. Rao and Melissa A. Duarte and S Wu and C. -S. Chiang and Lars Anders and Richard A. Young and Eric P. Winer and Antony Letai and William T. Barry and Jason S. Carroll and Henry W. Long and Myles Brown and Xiaole Shirley Liu and Clifford A. Meyer and James E. Bradner and Korn{\'e}lia Poly{\'a}k},
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in several models of cancer, have not been evaluated in TNBC. These inhibitors displace BET bromodomain proteins such as BRD4 from chromatin by competing with their acetyl-lysine recognition modules, leading to inhibition of oncogenic transcriptional programs. Here we report the preferential sensitivity of TNBCs… CONTINUE READING
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Outcomes by tumor subtype and treatment pattern in women with small, node-negative breast cancer: a multi-institutional study.

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