Response acceleration in post-translationally regulated genetic circuits.

  title={Response acceleration in post-translationally regulated genetic circuits.},
  author={Alexander Y. Mitrophanov and Eduardo A. Groisman},
  journal={Journal of molecular biology},
  volume={396 5},
Transcription factors must often be chemically modified to perform their functions. Yet, it is not known whether the mechanisms that bring about such modifications impact the quantitative or kinetic properties of gene expression. Phosphorylation controls the activity of regulatory proteins of the two-component system family, which constitutes a prevalent form of bacterial signal transduction. These proteins are phosphorylated/dephosphorylated by cognate sensor proteins in response to specific… CONTINUE READING


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