Responding to infection and apoptosis--a task for TH17 cells.

  title={Responding to infection and apoptosis--a task for TH17 cells.},
  author={Corinna F. Brereton and J Magarian Blander},
  journal={Annals of the New York Academy of Sciences},
Two of the critical cytokines required for the differentiation of T helper 17 (T(H)17) cells from naive CD4 T cells are transforming growth factor-beta (TGF-β) and interleukin-6 (IL-6). Innate recognition of apoptotic cells in the presence of Toll-like receptor engagement directs the simultaneous synthesis of these cytokines by antigen-presenting cells (APCs), and as such provides a cytokine milieu that favors T(H)17 cell induction. In this situation, APCs are activated in response to ligands… CONTINUE READING