Respirovirus C protein inhibits activation of type I interferon receptor‐associated kinases to block JAK‐STAT signaling

@article{Kitagawa2019RespirovirusCP,
  title={Respirovirus C protein inhibits activation of type I interferon receptor‐associated kinases to block JAK‐STAT signaling},
  author={Yoshinori Kitagawa and Mayu Yamaguchi and Miki Kohno and Madoka Sakai and Masae Itoh and Bin Gotoh},
  journal={FEBS Letters},
  year={2019},
  volume={594}
}
Respirovirus C protein blocks the type I interferon (IFN)‐stimulated activation of the JAK‐STAT pathway. It has been reported that C protein inhibits IFN‐α‐stimulated tyrosine phosphorylation of STATs, but the underlying mechanism is poorly understood. Here, we show that the C protein of Sendai virus (SeV), a member of the Respirovirus genus, binds to the IFN receptor subunit IFN‐α/β receptor subunit (IFNAR)2 and inhibits IFN‐α‐stimulated tyrosine phosphorylation of the upstream receptor… 
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